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Providers > Physicians > Hua Huang
Our Lab Studies the Signaling and Transcriptional Regulation of Allergic Immune Responses and T Helper Cell Differentiation
CD4+ T helper cells (Th) are of critical importance in health and in disease. Many types of Th cell-mediated immune responses have been uncovered. Each type of Th responses is carried out by a specialized CD4+ Th subset and by a specialized innate effector cells. For example, type-2 immune responses is mounted by Th2 cells, as well as Th2 cytokine-producing innate effector cells, such as basophils, eosinophils and mast cells. Type-1 immune responses provide cellular defense against infection with intracellular pathogens, whereas Type-2 immune responses help antibody responses. Type-2 immune responses have also been shown to be dominant immune responses in allergic diseases and allergic asthma. Type-3 and 9 immune responses cells exert their biological effects on basophil and mast cell differentiation. Type-17 immune responses are critical in recruiting neutrophils, inducing chemokine production, and causing inflammation and fibrosis. Type-22 immune responses are involved in epidermal immunity and remodeling.
Our lab is interested in studying regulation of type-2 immune responses in general, specifically, we actively investigate three areas of research. Helper cell differentiation, innate type-2 effector cell differentiation, and interaction between CD4 Th cells and bone marrow allergic progenitor cells.
Xiaopeng Qi, Lee Chaves, Yonghua Zhuang, Yuhong Chen, Demin Wang, Jacob Chahon, Brian Graham, Keitaro Ohmori, and Hua Huang. Antagonistic regulation by transcription factors C/EBPa and MITF specifies basophil and mast cell fates. Immunity, 39, 97-110; 10.1016/j.immuni.2013.06.012, published online, July 18, 2013
Zhihong Chen, Shanze Wang, Nkiruka Erekosima, Jessie Hong, Xiaopeng Qi, Yapeng Li, Patricia Merkel, Vijaya Nagabhushanam, Eugene Choo, Rohit Katial, Rafeul Alam, Hong Wei Chu, Yonghua Zhuang, Meiling Jin, Chunxue Bai, and Hua Huang. IL-4 confers resistance to IL-27-mediated suppression on CD4+ T cells by impairing STAT1 signaling. J Allergy Clin Immunol, in press, 2013.
Xiaopeng Qi, Jun Nishida, Lee Chaves, Keitaro Ohmori, and Hua Huang. C/EBPa is critical for interleukin-4 expression in response to FceRIa receptor cross-linking. JBC. 286:16063 (2011).
Keitaro Ohmori, Yuchun Luo, Yi Jia, Jun Nishida, Zhengqi Wang, Kevin D. Bunting, Demin Wang, and Hua Huang. IL-3 Induces Basophil Expansion In Vivo by Directing Granulocyte-Monocyte Progenitors to Differentiate into Basophil Lineage-Restricted Progenitors in the Bone Marrow and by Increasing the Number of Basophil/Mast Cell Progenitors in the Spleen. J Immunol 182: 2835-2841 (2009).
Zhu YC, Chen L, Huang Z, Alkan S, Bunting KD, Wen RR, Wang D, and Huang H. IL-5 primes Th2 cytokine-producing capacity in eosinophils through a STAT5-dependent mechanism. Cutting Edge, J Immunol 173:2918-2922 (2004).
Zhang Y, Apilado R, Coleman J, Ben-Sasson SZ, Tsang S, Hu-Li J, Paul WE and Huang H. Inteferon gamma stabilizes the T helper cell type 1 phenotype. J Exp Med 194(2):165-172 (2001).
1999-2005: Assistant Professor (promoted to Associate Professor with tenure), the Department of Cell Biology, Loyola University Chicago, Stritch School of Medicine.
1997-1999: Intramural Research Fellow, the Laboratory of Immunology, NIAID, NIH.
1995-1997: Leukemia Society Fellow, the Laboratory of Immunology, NIAID, NIH.
1993-1995: Leukemia Society Fellow, the Department of Molecular Biology, Princeton University.
1989-1993: Research Assistant, the Department of Zoology, University of Wisconsin.
1988-1989: Visiting Scholar, Immunology, Radiation Effects Research Foundation (Hiroshima,
1985-1986: Lecturer (on leave), Liu Zhou Nursing School (Liu Zhou, P. R. China).
1984-1988: Research Associate, the Laboratory of Industrial Hygiene, Ministry of Public Health (Beijing, P. R. China).
2006-Present: Ad hoc reviewer for Specialized Clinically-Oriented Ventures in Environmental Research (DISCOVER) Center, NIEHS, NIH
2005-Present: Ad hoc reviewer for Immunity and Host Defense Study Section, NIH
1999-Present: Member of American Association of Immunology.
2004: Travel Award by the Federation of Clinical Immunology Societies (FOCIS).
2001: The Lydia Schweppe Immunology Career Development Award. 2000: NIH K22 Research Career Award
1994: Leukemia Society of America Fellowship.
1998: Certification of Appreciation from the Radiation Effects Research Foundation (Japan)
1988: Visiting Scholarship awarded by the Radiation Effects Research Foundation (Japan)
2005-Present: Associate Professor, Integrated Immunology, University of Colorado Denver (Denver, Colorado).
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