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Providers > Researchers > Claudia V. Jakubzick
Pulmonary dendritic cells acquire antigen in the airway and lung and then migrate through lymphatic vessels to the mediastinal lymph node, where they present antigen and stimulate an immune response. Because the airway frequently encounters foreign substances, the antigen-presenting role of DCs is critical for the maintenance of pulmonary health. Ideally, harmless antigens induce tolerance, whereas harmful antigens promote effector immune responses. Understanding the mechanisms that regulate these immunological outcomes is my primary research goal.
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