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Providers > Researchers > David W H Riches
Research into lung inflammation and fibrosis. 1. TNF-receptor family members play a key role in inflammation, innate and adaptive immunity and apoptosis. The goals of our lab are two fold. First, we are addressing fundamental questions about how the prototypic receptor, TNF-R1, initiates different responses. Second, we are investigating how TNF-R1 and other family members regulate apoptosis in pulmonary myofibroblasts. These latter studies are aimed at furthering our understanding of the mechanisms that lead to the development of pulmonary fibrosis. 2. The subcellular localization of the TNF receptor, TNF-R1, determines signaling responses. 3. TRUSS, a TNF receptor scaffolding protein. 4. Mechanism of myofibroblast apoptosis and survival in pulmonary fibrosis.
Professor, Department of Immunology & Microbiology
Professor, Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine
2001: The American Association of Immunologists
1997: American Society for Biochemistry and Molecular Biology
1985: American Society for Cell Biology
1984: Society for Leukocyte Biology
S.K. Frankel, B. Moats-Staats, C. Cool, M.W. Wynes, A.D. Stiles and D.W.H. Riches. 2005 Pulmonary Expression of Human Insulin-Like Growth Factor-IA by Alveolar Type II Epithelial Cells Promotes Adenomatous Hyperplasia but Not Pulmonary Fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. Accepted for publication.
J.E.S. Doan, D.A. Windmiller and D.W.H. Riches. 2004. Regulation of TNF-R1 signaling. Lipid raft dependency of p42mapk/erk2 activation, but not NF-kB activation. J. Immunol. 172:7654-7660.
S.M. Soond, J.L. Terry, J.D. Colbert and D.W.H. Riches. 2003. TRUSS, a novel tumor necrosis factor receptor-1 scaffolding protein that regulates the activation of transcription factor NF-kB. Mol. Cell. Biol. 23:8334-8443.
M.W. Wynes and D.W.H. Riches. 2003. Induction of macrophage insulin-like growth factor-I expression by the Th2 cytokines IL-4 and IL-13. J. Immunol. 171:3550-3559
V. Cottin, J.E.S. Doan and D.W.H. Riches. 2002. Restricted localization of the TNF receptor CD120a to lipid rafts. A novel role for the death domain. J. Immunol. 168:4095-4102.
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