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Providers > Researchers > Joseph J. Lucas
Cell cycle control in normal and cancer cells. Signal transduction in mast cells and T lymphocytes. My major research interest is the role of G1-phase cyclin-dependent kinases and their associated proteins and substrates in cell cycle control in normal and transformed cells. These complexes of molecules are important as components of them are deficient in many tumors derived from T and B-lymphocytes and from breast epithelial cells. I am also involved in studies designed to delineate the signal transduction pathways which lead to effector functions in T lymphocytes and in mast cells. Elucidation of these pathways is important in understanding a variety of immunological disorders.
Domenico, J., LUCAS, J. J., Fujita, M. and Gelfand, E. W. Susceptibility to vaccinia virus infection and spread is determined by age at infection, allergen sensitization, and mast cell status. Int. Arch. Allergy Immunol. 158:196-205 (2012).
Shin, Y.S., Takeda, K., Shiraishi, Y., Jeong, Y.Y., Domenico, J., Jia, Y., Spallek, R., Singh, M. LUCAS, J.J., and Gelfand, E.W. Microbial heat shock protein 65 attenuates airway hyperresponsiveness and inflammation by modulating the function of dendritic cells. J. Immunol. 189:3404-3410 (2012).
Okamoto, M., Takeda, K., LUCAS, J. J., Joetham, A., Yasutomo, K. and Gelfand E. W. Low-dose lipopolysaccharideaffects lung allergic responses by regulating Jagged1 expression on antigen-pulsed dendritic cells. Int. Arch. Allergy Immunol. 157(1):65-72 (2012).
Li, G., Domenico, J., LUCAS, J. J. and Gelfand, E. W. “Identification of multiple cell cycle regulatory functions of p57Kip2 in human T lymphocytes.” J. Immunol. 173:2383-2391(2004).
LUCAS, J. J., Domenico, J. and Gelfand, E. W. “Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells.” Molec. Cancer Res. 2:105-114(2004).
Link to Faculty Publications
No current positions.
Recipient of Damon Runyon Memorial Fund Fellowship
Recipient of NIH Fellowship
American Heart Association Established Investigatorship
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