Evaluating Skin Barrier Changes in Food Allergy

Trial Objectives

Food allergies are complex, and researchers are studying new ways to predict who might develop allergies in the future. In this study, researchers are trying to determine if skin reactions during an oral food challenge can predict food allergies. They also are evaluating if a biologic called omalizumab, which is currently approved to treat asthma, can help people with food allergies.

Researchers are comparing the skin of people with food allergies to those without food allergies in the first phase of the study. Volunteers with food allergies will undergo 2 oral food challenges and will receive 4 months of treatment with omalizumab. At clinic visits, skin tape strips will be collected to measure a number of markers of overall skin health to see if they improve. Volunteers without food allergies will have skin tape strips collected at a single clinic visit, which will help provide a comparison for researchers.