Pyrazinamide Level
Test Code
PKPZA
Description
Therapeutic Drug Monitoring (TDM) of pyrazinamide (PZA) is used to optimize dosing, ensuring efficacy while minimizing toxicity. PZA is a first-line anti-tuberculosis (TB) drug, primarily effective against Mycobacterium tuberculosis.
Collect
Collect Serum in an 8-10 mL plain red top tube. Any other type of tube may influence accurate drug level quantification.
Patient Prep
Allow to clot for 30 minutes, separate serum from cells immediately by centrifugation and aliquot into a labeled polypropylene or similar plastic tube. Use a separate tube for each test ordered. Allow room for expansion of sample inside tube.Preferred volume: 2 mL of serum (or plasma).
Minimum volume: 0.5 mL serum (or plasma).
Pediatric Collection
If minimum volume cannot be obtained, samples can be ran with dilution calculations. 5x maximum dilution to be allowed.
Unacceptable Conditions
Thawed samples for greater than 24 hours
Storage Transport Temp
Fully complete PK requisition, Missing elements may delay resulting.
Ship samples via overnight delivery with appropriate amount of dry ice to remain frozen upon arrival.
Stability
Freeze at -70C if possible, but at minimum -20C. Up to 24 hours at room temperature.
Notes
Ship samples to be received Monday through Friday. Do not ship on Friday or Saturday.
Performed
Monday - Friday
Methodology
LC/MS/MS
Turnaround Time
Within 10 business days. Weekends and holidays may delay results until following business day.
Department
Pharmacokinetics Lab
Synonyms
GC/MS (Pyrazinamide, Level), pharmacokinetics (Pyrazinamide, Level), mycobacteria (Pyrazinamide, Level), PZAH
Study Offerings
RUO
CAP/CLIA
Reference Interval
By Report
CPT Code
80299
New York Approved
No: Run with Waiver
FDA
LDT