Advanced Diagnostic Laboratories

Scleroderma (Systemic sclerosis) Panel 12

Test Code

SSP12

Description

Collect

Collect in a plain red top or SST tube

Pediatric Collection

Pediatric Collection
Minimum volume: 0.1 mL

Storage Transport Temp

Send serum Priority Overnight via FedEx and in a well-insulated container frozen on dry ice.

Stability

Frozen at -70°C: 1 year. Serum samples may be stored at +2°C to +8°C for up to 14 days if necessary.

Notes

National Jewish Health Advanced Diagnostic Laboratories offers a Scleroderma (systemic sclerosis) Panel to aid in the diagnosis of systemic sclerosis. When combined with clinical features, the Scleroderma Antigen Panel can aid clinicians in making a diagnosis of systemic sclerosis and related conditions. The Scleroderma Antigen Panel provides a qualitative in vitro assay for human antibodies present in serum of the IgG class to 12 different antigens.

Performed

Weekly

Methodology

Immunoblot

Turnaround Time

2-12 days

Department

Immunology Lab - Diagnostic

Synonyms

Scl-70, CENP A, centromere A, CENP B, centromere B, RP11, RP155, Fibrillarin, NOR90, Th/To, PM/Scl-100, PM/Scl-75, Ku, Ro-52

Study Offerings

RUO
CAP/CLIA

Reference Interval

Negative 0-5 Units
Borderline 6-10 Units
Positive 11-50 Units
Strong Positive >50 Units

Interpretation

Antibodies to the antigens are determined by an immunoblot assay. The color developed for each antigen is determined by densitometry and the intensity of the color is proportional to the antibody reactivity. The results are given in arbitrary intensity units.